Nanobiotix, a late clinical-stage nanomedicine company focused on the local treatment of cancer, on Monday announced that its preclinical data demonstrated that its leading radioenhancer nanoparticle, NBTXR3, actively stimulates the host immune system to attack tumor cells.
These data from the ongoing NBTXR3 immuno-oncology preclinical program were presented at one of the leading global immuno-oncology conferences, the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), being held November 9-13, 2016 in National Harbor, Maryland, USA (Paris S., Pottier A., Levy L., and Lu B. Hafnium oxide nanoparticles, a radiation enhancer for in situ cancer vaccine).
Laurent Levy, CEO of Nanobiotix, commented: “These exciting data show that NBTXR3 could be a potential game changer in Immuno-oncology combination landscape. This raises the possibility of synergies between NBTXR3, radiotherapy and immunotherapies. On the top of existing core developments of our product as a single agent, this is opening new doors for industrial collaborations.”
Potential of NBTXR3 in Immuno-Oncology
Presented study results showed that radiotherapy with NBTXR3 elicits a marked enhancement of Immunogenic Cell Death (ICD) compared to radiotherapy alone across different cancer cell lines, in radioresistant or radiosensitive models.
Second experiment showed that use of NBTXR3 in combination with radiotherapy resulted in a control on the untreated tumor and a statistically significant increase of overall survival. No abscopal effect was observed in control groups and group treated with radiation therapy alone.
A third experiment has demonstrated that NBTXR3 combined with radiotherapy could be used to create a vaccine ex vivo with a higher rate of long term vaccination success when compared to radiotherapy alone.
Elsa Borghi, CMO of Nanobiotix commented: “Although immunotherapies hold great promise in treating cancer, one of the main barriers is that most of tumors do not provoke an immune response, which renders immunotherapy ineffective in many patients. The findings from this research indicate that NBTXR3 could have the potential to transform a tumor into an in situ vaccine. It could convert an immunologically ‘cold’ tumor, which does not provoke an immune response, to a ‘hot’ tumor, which induces an immune response and therefore provokes a host immune response to attack tumor cells.”